Endocrine Abstracts

We have investigated cell proliferation and apoptosis in Cyp11b1 null (ko) mice. Reduced glucocorticoid (corticosterone) synthesis in ko mice is associated with increased progesterone and deoxycorticosterone and the development of adenomyosis. Numbers of putative uterine stem cells were assessed in wild type (wt) and ko at an age (10–12 months) when the onset of adenomyosis was considered imminent. Mice were infused with bromodeoxyuridine (BrdU) for seven days then killed...

Radioactive iodine (RAI) therapy is the usual treatment of choice for hyperthyroidism. We have demonstrated a success rate of 88% (euthyroidism or hypothyroidism) over a 5-year period. We are very happy to recommend RAI, however patients still express concerns.There is little literature available about patients’ reactions to RAI: to our knowledge, only two studies. We performed a survey of our RAI treated patients. Of 143 patients contacted, 87 repl...

Chromaffin cells from adrenal medulla are the main source of epinephrine and norepinephrine hormones which are known to mediate so called fight-or-flight response to multiple environmental stress conditions. Chromaffin cells together with sympathetic neurons share the same sympathoadrenal cell lineage, but in contrast to neurons they maintain their proliferation during whole life span. However, little is known about chromaffin cells regeneration in an adult adrenal medulla.</p...

Increased RhoA/Rho-kinase (ROK) signalling is known to impair erectile function. Spontaneously hypertensive rats (SHR) over-express penile RhoA and show an impaired erectile response. We tested treatments known to inhibit RhoA activation, on erectile function and sildenafil responsiveness in SHR. SHR have been treated for two weeks with atorvastatin (5 and 30 mg/Kg/day), or with elocalcitol (30 μg/Kg/day), a vitamin D receptor (VDR) agonist. The normotensive Wistar Kyoto ...

Objectives: Radical prostatectomy is an effective therapy for men with clinically localized prostate cancer. A significant number of men develop erectile dysfunction after radical prostatectomy (PPED) due to intraoperatory cavernous nerve injury causing hypoxia and fibrosis of corpus cavernosus. We established an experimental model of bilateral cavernous neurotomy (BCN) in the rat in order to investigate whether sildenafil treatment in PPED patients could prevent penile tissue...

Females release 2–3 fold greater GH compared with males whilst maintaining similar IGF-I levels. IGF-I generation tests in healthy subjects suggest this discordancy results from resistance to GH in females. In GHD females the presumed relative insensitivity to GH is reflected by a lower basal IGF-I and higher GH maintenance doses during replacement. GHD adults of childhood- (CO) and adult-onset (AO) show CO-GHD adults to have lower basal IGF-I values and require higher ma...

Background: red blood cells (RBC) membrane fluidity in patients with type 2 diabetes mellitus (T2DM) can be influenced by various factors like oxidative stress, aging, glycosylation, lipid homeostasis and exposure to nutrients.Objective: To analyze RBC membrane fluidity in patients with long-duration T2DM (more than 10 years), looking for any differences between patients without and with macroangiopathy (vascular diabetic foot).Met...

Introduction: Glucagon-like peptide-1(GLP-1) agonists are widely used for treatment of type 2 diabetes(T2D). To date a number of reports have described improvements in glucose control with the addition of a GLP-1 agonist to the insulin regime in treatment of type 1 diabetes(T1D). From a physiological perspective there is credence to the notion that a GLP-1 agonist will lower glucose levels in people with T1D as they do in T2D. GLP-1 is an endogenous hormone th...

Introduction: Acromegaly is a rare endocrinologic disease most commonly caused by an excess of growth hormone (GH) produced by a benign pituitary adenoma. Besides diverse systemic manifestations, acromegaly is also associated with a range of oral-dental problems. To date limited research has been conducted on how oral-dental pathologies affect the oral health-related quality of life (OHRQoL) in patients with acromegaly and growth hormone-producing pituitary adenomas. To our kn...

Context: Polycystic ovary syndrome (PCOS) is a complex endocrine disease that affects women of reproductive age and characterised by biochemical and clinical androgen excess.Aim: To review the available literature on the effectiveness of the various pharmacological interventions on androgen hormones in women with PCOS.Data source: We searched PubMed, MEDLINE, Scopus, Embase, Cochrane library and the Web of Science in April 2020 and...